Both of these teams are pretty tired, so there'll be a huge burden on the starters to give them some innings. The Reds will have their work cut out for them with Doug Fister, making his 3rd start of the season. He went 7 in his last start, giving up only one run.
Johnny Cueto will be on the hill for the good guys, who threw a shutout against the Padres in his last outing. We need Johnny Cueto to do Johnny Cueto things, which he's traditionally done by posting a 2.14 ERA in his career at Nationals Park.
The bullpen is pretty spent.