Joe was just 15 years, 10 months, and 11 days old when he came into a blow-out game against the St. Louis Cardinals. The Reds lost that day 18-0 and Joe wouldn't be back in a Reds uniform until 1952. Joe came into the game with the Reds trailing 13-0. He walked one and retired two batters before seeing Stan Musial on deck. Nuxhall then melted down, allowing five earned runs and failing to retire another batter. His line was 2/3 of an inning, 2 hits, 5 walks, 5 runs allowed (all earned). His ERA when he left was 67.50. Joe had this to say about his first game:
"Probably two weeks prior to that, I was pitching against seventh, eighth and ninth graders, kids 13 and 14 years old. All of a sudden, I look up and there's Stan Musial"
Overall, Joe handled Musial pretty well in their careers.